Molecularly imprinted polymers as synthetic mimics of bioreceptors. 1. General principles of molecular imprinting
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چکیده
منابع مشابه
Mimics of the binding sites of opioid receptors obtained by molecular imprinting of enkephalin and morphine ( molecular recognition / synthetic polymers / ligand - receptor interactions / molecularly imprinted sorbent assay )
Molecular imprinting of morphine and the endogenous neuropeptide [Leu5]enkephalin (Leu-enkephalin) in methacrylic acid-ethylene glycol dimethacrylate copolymers is described. Such molecular imprints possess the capacity to mimic the binding activity of opioid receptors. The recognition properties ofthe resultant imprints were analyzed by radioactive ligand binding analysis. We demonstrate that ...
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Artificial receptors have been in use for several decades as sensor elements, in affinity separation, and as models for investigation of molecular recognition . Although there have been numerous publications on the use of molecular modeling in characterization of their affinity and selectivity, very few attempts have been made on the application of molecular modeling in computational design of ...
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Artificial neural network (ANN) implementing the back-propagation algorithm was applied for the calculation of the imprinting factors (IF) of molecularly imprinted polymers (MIP) as a function of the computed molecular descriptors of template and functional monomer molecules and mobile phase descriptors. The dataset used in our study were obtained from the literature and classified into two dis...
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2009
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.0007e4